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PICO
Question: Among children with acute lymphoblastic leukemia, are race-specific sociodemographic factors associated with differences in adherence to oral chemotherapy?
Question type: Descriptive
Study design: Prospective cohort
Investigators from multiple Children’s Oncology Group (COG) centers in the United States evaluated factors associated with adherence to daily oral 6 mercaptopurine (6MP) regimens in children with acute lymphoblastic leukemia (ALL), and the impact of nonadherence on relapse. Study participants were children and youth, aged <21 years, with ALL in first remission and receiving maintenance therapy with 6MP. Only children with self-identified racial categories of Asian American, African American, or non-Hispanic white were enrolled. Parents of study children completed questionnaires to provide information on sociodemographic variables. Data on 6MP administration, for up to …
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