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PICO
Question: Among children with autism spectrum disorders and developmental delay, is there prenatal agricultural pesticide exposure?
Question type: Harm/causation
Study design: Population-based, case-control
Investigators from multiple institutions evaluated data from the Childhood Autism Risks from Genetics and Environment (CHARGE) study in California to assess the association of prenatal agricultural pesticide exposure and the subsequent risk of developing autism spectrum disorder (ASD) or developmental delay (DD). Children 2–5 years of age with a diagnosis of ASD or DD, seen in either regional Department of Developmental Services centers or other referral clinics in California, were enrolled. Typically developing (TD) children were recruited from the general population and frequency matched to an autism …
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