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Dr Holmes has disclosed no financial relationship relevant to this commentary. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.
Human cannabinoids play a significant role in development and maturation of the brain. Exposure to the psychoactive cannabinoid in marijuana, Δ9-tetrahydrocannabinol (THC), mimics human cannabinoids and affects the function of the human endocannabinoid system.1 Following synthesis, human cannabinoids are instantly degraded but after using marijuana the concentration of THC in the body is higher than that achieved by human cannabinoids. In addition, THC circulates for a prolonged period of time. These changes result in impaired growth, development, and function …
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