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PICO
Question: Among individuals with pertussis, are those who have received at least 1 dose of pertussis vaccine more likely to have infection due to Bordetella pertussis strains that are pertactin-deficient compared to those who are unvaccinated?
Question type: Descriptive
Study design: Retrospective cohort
Investigators from 8 states and the Centers for Disease Control and Prevention conducted a retrospective study to assess the association between pertactin-deficient (PRN−) Bordetella pertussis strains and both clinical presentation and vaccination receipt. PRN is a protein on the outer membrane of Bordetella that facilitates binding to host cells …
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