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PICO
Question: Among children aged 2–9 years, does the immune response differ when induced by live attenuated influenza vaccine compared to inactivated influenza vaccine?
Question type: Intervention
Study design: Randomized controlled
Investigators from multiple institutions compared the mucosal and systemic immune responses induced by live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV). Healthy children recruited from the Rochester, NY community and Dartmouth, NH clinics were enrolled in either autumn 2010 or autumn 2011. The same seasonal influenza vaccine was used in both years. Children were randomly assigned to receive LAIV intranasally twice, or IIV intramuscularly followed by LAIV intranasally. Blood samples were …
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