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PICO
Question: Among pediatric patients requiring mechanical ventilation for acute respiratory failure, is a protocol-driven sedation plan superior to usual care with regard to duration of mechanical ventilation and sedation-related adverse events?
Question type: Treatment
Study design: Cluster randomized
Investigators from multiple institutions who are part of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI) assessed the effect of a nurse-implemented goal-directed sedation protocol on clinical outcomes in children requiring mechanical ventilation for acute respiratory failure. Using a nonblinded multicentered cluster randomized clinical trial design, investigators randomized PICUs recruited from the PALISI network to either receive the protocol-driven intervention or to continue their usual approach to sedation management. The intervention included use …
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