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PICO
Question: Among infants at high risk for developing peanut allergy, does the early introduction of dietary peanuts prevent development of peanut allergy?
Question type: Intervention
Study design: Prospective randomized controlled
To determine whether early exposure to peanut-containing foods is more likely to induce or prevent allergy to peanuts, the Immune Tolerance Network, an international research group, enrolled children at high risk of developing allergy in the LEAP study (Learning Early About Peanut Allergy), a randomized, open label, controlled trial carried out at a single site in the United Kingdom.
Participants between 4 and 11 months old with severe eczema, egg allergy, or both were stratified into 2 cohorts based on their reaction to a skin-prick test for peanut allergy. One cohort included infants with no measureable …
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