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Question: Among children treated with glucocorticoids for acute lymphoblastic leukemia, does screening detect extensive hip osteonecrosis before symptom development?
Question type: Descriptive
Study design: Prospective cohort
Investigators from St Jude Children’s Research Hospital conducted a prospective study in children with newly diagnosed acute lymphoblastic leukemia (ALL) to identify risk factors for hip osteonecrosis and to determine the utility of early screening with magnetic resonance imaging (MRI) in identifying patients with asymptomatic hip osteonecrosis. Between 2000 and 2007, consecutive children ≤18 years of age with newly diagnosed ALL treated with a single, risk-stratified chemotherapy protocol containing fixed glucocorticoid doses and schedules were enrolled in the study. MRI examinations of both hips were performed at approximately …
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