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PICO
Question: Among autopsied stillborn infants, is there an association between neonatal fatty liver disease and maternal diabetes?
Question type: Causation
Study design: Retrospective cohort
To determine the association between maternal diabetes mellitus (DM) and neonatal hepatic steatosis, investigators from Washington University in St. Louis and Seattle Children’s Hospital performed a retrospective cohort study of autopsied stillborn infants. The case group was stillborn infants with a history of maternal DM type 1 or type 2, and gestational DM. The control group consisted of stillborn infants delivered to women who had no history of DM matched for gestational age and degree of maceration. There was oversampling of controls born to obese mothers, infants born at >90th percentile weight for gestational …
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