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PICO
Question: Among children aged 2 days to 18 years who are resuscitated but remain comatose following an out-of-hospital cardiac arrest, do those treated for 2 days with therapeutic hypothermia have greater survival with acceptable cognitive function compared to those whose temperature is maintained in a normal range?
Question type: Prognosis
Study design: Randomized controlled
Investigators at 38 sites in the Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCAOH) trial compared the efficacy of therapeutic hypothermia (TH) with normothermia (NT) following out-of-hospital cardiac arrest (CA). They enrolled children 2 days to18 years of age with an out-of-hospital CA who were resuscitated but remained unconscious with a Glasgow Coma Motor-response subscale score of ≤4. Eligible patients were enrolled in the study within 6 hours of CA and randomized to 48 hours …
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