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PICO
Question: Among breast cancer survivors, is a history of breastfeeding associated with differences in prognosis and survival based on tumor subtype?
Question type: Prognosis
Study design: Retrospective cohort
Investigators from multiple institutions studied the lifetime effect of breastfeeding on outcomes following breast cancer. Participants were women from 2 prospective breast cancer cohorts of breast cancer survivors. Intrinsic tumor subtype was determined by the PAM50 gene expression assay and classified as one of 4 subtypes, including luminal A, luminal B, HER2 enriched, and basal-like/triple negative. Breastfeeding data were obtained from participant questionnaires collected at study enrollment and consisted of ever/never and cumulative …
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