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PICO
Question: Among survivors of childhood acute lymphoblastic leukemia treated with chemotherapy but not with radiation, what types and severity of long-term neurocognitive deficits exist as compared to healthy controls?
Question type: Prognosis
Study design: Meta-analysis
Investigators from Yale conducted a systematic review to determine long-term neurocognitive functioning following chemotherapy among childhood acute lymphoblastic leukemia (ALL) survivors compared to age- and gender-matched healthy controls. Studies conducted between 1966 and 2014 were included in the review if they evaluated neurocognitive outcomes in ALL survivors who met the following criteria: were diagnosed with ALL at age <21 years, were ≥5 years after diagnosis or had completed cancer treatment ≥2 years previously, had no history …
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