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PICO
Question: Among children <5 years of age who acquire Helicobacter pylori infection, are specific host and/or pathogen profiles associated with persistent as compared to transient infection?
Question type: Descriptive
Study design: Prospective cohort
Investigators from Chile sought to evaluate host- and pathogen-related factors associated with persistent Helicobacter pylori infections among healthy children. For the study, 2 cohorts were evaluated every 3 months for 18–57 months. The birth cohort included infants enrolled as newborns. The 1-year-old cohort enrolled 12-month-old children (±3 months). At each visit, a stool sample was collected and tested for H pylori by ELISA. H pylori infection was defined as ≥1 ELISA-positive stool, as persistent if …
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