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PICO
Question: Among infants hospitalized with bronchiolitis, is a minimum oxygen saturation target of 90% versus 94% associated with equivalent outcomes?
Question type: Intervention
Study design: Randomized controlled
Investigators from multiple institutions in the United Kingdom conducted a randomized controlled trial to determine if outcomes were equivalent for infants hospitalized with bronchiolitis using an oxygen saturation (SpO2) target of ≥90% compared to ≥94%. For the study, previously healthy infants from 6 weeks to 12 months of age hospitalized with acute viral bronchiolitis were randomized to monitoring with standard or modified pulse oximeters. Parents and health care providers were blinded as to study infants’ group allocation. With the modified oximeters, oxygen saturations between 85% and 100% were artificially skewed upwards, so that an actual …
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