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PICO
Question: Among children with ADHD, is psychostimulant use associated with an increased risk of the development of new-onset tics or worsening of existing tics as compared to placebo?
Question type: Harm/Causation
Study design: Meta-analysis
Investigators from Yale performed a meta-analysis to determine the association between psychostimulant use and the development of new tics or worsening of existing tics. For the meta-analysis, only English-language, published, randomized double-blinded placebo-controlled trials that compared psychostimulant medication with placebo were considered. Also, only trials involving participants <18 years of age with ADHD or a hyperkinetic disorder and …
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