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PICO
Question: Among healthy infants, do those at risk of developing asthma have altered gut microbiota?
Question type: Descriptive
Study design: Case-control
Investigators from multiple institutions in Canada sought to determine if different characteristics of gut microbiota in early infancy were associated with an increased risk of developing asthma. Participants were enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study. The CHILD study is a prospective, multicenter general population birth cohort designed to assess development of asthma and atopic disease in which questionnaires, physical examination, and skin testing were used to classify clinical phenotypes at 1 year of age. A subset of infants enrolled in the CHILD cohort were included in this study based on availability of stool samples collected at 3 and 12 months of age. Study participants were placed into 4 phenotypes at 1 …
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