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PICO
Question: Among infants <3 months of age hospitalized for pertussis, are there early markers of disease severity that predict death?
Question type: Prognosis
Study design: Case-control
Investigators from the California Department of Public Health and University of California conducted a case-control study to determine the risk factors associated with infant death from pertussis. The investigators reviewed 1998–2014 California Department of Public Health surveillance data to identify infant pertussis deaths (cases). Controls were infants who were hospitalized with nonfatal pertussis. One to 4 controls were matched to each case by age, county of residence, and closest symptom onset date. All …
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