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American Academy of Pediatrics
Clinical Pharmacology & Therapeutics

Pharmacokinetic-Modeled Treatment for Neonatal Abstinence Syndrome

AAP Grand Rounds March 2016, 35 (3) 27; DOI: https://doi.org/10.1542/gr.35-3-27
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Hall ES, Meinzen-Derr J, Wexelblatt SL. Cohort analysis of a pharmacokinetic-modeled methadone weaning optimization for neonatal abstinence syndrome. J Pediatr. 2015; 167( 6): 1221– 1225; doi: 10.1016/j.jpeds.2015.09.038OpenUrlCrossRefPubMed

Key words
  • pharmacokinetic
  • neonatal abstinence syndrome
  • methadone

PICO

Question: Among infants with neonatal abstinence syndrome, does treatment with a revised methadone weaning protocol result in improved treatment outcomes relative to a standard protocol?

Question type: Intervention

Study design: Pre-post

Investigators from Cincinnati Children’s Hospital conducted a pre-post interventional study to evaluate the treatment outcomes using a revised protocol compared to a standard protocol for treating infants with neonatal abstinence syndrome (NAS). The revised protocol was based on the results of a pharmacokinetic modeling study (PK protocol).1 The PK protocol used a larger loading dose, a more rapid taper of the dose, and fewer treatment doses than the standard protocol.

For the study, eligible infants were recruited from 6 nurseries in southwest Ohio and were >34 …

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AAP Grand Rounds
Vol. 35, Issue 3
1 Mar 2016
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Pharmacokinetic-Modeled Treatment for Neonatal Abstinence Syndrome
AAP Grand Rounds Mar 2016, 35 (3) 27; DOI: 10.1542/gr.35-3-27

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Pharmacokinetic-Modeled Treatment for Neonatal Abstinence Syndrome
AAP Grand Rounds Mar 2016, 35 (3) 27; DOI: 10.1542/gr.35-3-27
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