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PICO
Question: Among infants with neonatal abstinence syndrome, does treatment with a revised methadone weaning protocol result in improved treatment outcomes relative to a standard protocol?
Question type: Intervention
Study design: Pre-post
Investigators from Cincinnati Children’s Hospital conducted a pre-post interventional study to evaluate the treatment outcomes using a revised protocol compared to a standard protocol for treating infants with neonatal abstinence syndrome (NAS). The revised protocol was based on the results of a pharmacokinetic modeling study (PK protocol).1 The PK protocol used a larger loading dose, a more rapid taper of the dose, and fewer treatment doses than the standard protocol.
For the study, eligible infants were recruited from 6 nurseries in southwest Ohio and were >34 …
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