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PICO
Question: In adolescents with severe premenstrual syndrome (PMS) and vitamin D deficiency, does vitamin D supplementation reduce mood disorders associated with PMS?
Question type: Intervention
Study design: Randomized, controlled
Researchers from multiple institutions sought to determine whether supplementing vitamin D-deficient adolescent girls with vitamin D-3 would improve emotional symptoms of premenstrual syndrome (PMS). This study was carried out at 2 academic centers in Italy from 2010–2012. Females 15–21 years of age were enrolled if they met standard diagnostic criteria of PMS, as outlined by the American College of Obstetrics and Gynecology (ACOG); scored in the severe to extremely severe levels of intensity on the Daily Symptoms Rating (DSR) validated scale that …
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