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PICO
Question: Among children with urinary tract infections, what are the demographic and clinical characteristics that are predictive of infections caused by bacteria resistant to narrow-spectrum antibiotics?
Question type: Descriptive
Study design: Cross-sectional
Investigators at multiple US institutions sought to determine which children with urinary tract infections (UTI) were likely to have pathogens resistant to narrow-spectrum antibiotics. Children who were 2–71 months of age and enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) or Careful Urinary Tract Infection Evaluation (CUTIE) studies were included (see AAP Grand Rounds, November 2015;34[5]:51).1 The RIVUR study included children with a first or second febrile or symptomatic UTI and grades I–IV vesicoureteral reflux (VUR), while the CUTIE study included children with a first or second …
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