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PICO
Question: Among National Collegiate Athletic Association football athletes, do serum neurofilament light levels increase with the number and magnitude of head impacts and does docosahexaenoic acid attenuate this increase?
Question type: Interventional
Study design: Randomized controlled
Investigators from multiple institutions conducted a randomized, double-blind controlled trial to examine the effects of various doses of docosahexaenoic acid (DHA) supplementation on plasma serum neurofilament light (NFL), a potential biomarker for head trauma-induced axonal injury. Eligible participants included National Collegiate Athletic Association football athletes at a single Division 1 program. Participants were stratified by their position of play and then randomized to 1 of 4 arms: oral ingestion of DHA for 5–7 days per week during summer football training, preseason camp, and the competitive season at (1) 2 g/day, (2) 4 g/day, …
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