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PICO
Question: Among children, is the amount of gluten intake during the first 2 years of life a risk factor for celiac disease?
Question type: Descriptive
Study design: Case control
Investigators from multiple institutions enrolled child participants from the Swedish site of The Environmental Determinants of Diabetes in the Young (TEDDY) study to assess the association between gluten intake before 2 years of age and the risk of developing celiac disease (CD). As part of the TEDDY study, participants were screened for CD annually beginning at age 2 years using serum tissue transglutaminase (TTGA). Participants with 2 consecutive positive TTGA samples were referred to their health care provider for evaluation of CD with an intestinal biopsy; a biopsy showing a Marsh score of …
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