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Investigators from multiple institutions studied the effect of the environment on asthma among 2 distinctive US farming populations—the Amish of Indiana and the Hutterites of South Dakota. These 2 populations were chosen because the prevalence of asthma in each is strikingly different (5% in Amish and 21% in Hutterites) despite having similar lifestyles with respect to most of the factors known to influence the risk of asthma (eg, large sibship size, minimal exposure to tobacco smoke and air pollution, long durations of breastfeeding) and similar genetic ancestry (both populations originated in Europe and have remained reproductively isolated since immigrating to the United States). One important difference between the 2 populations is that the Amish practice traditional farming …
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