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American Academy of Pediatrics
Endocrinology

Neurodevelopment After Neonatal Hypoglycemia

AAP Grand Rounds November 2017, 38 (5) 53; DOI: https://doi.org/10.1542/gr.38-5-53
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Source: McKinlay CJD, Alsweiler JM, Anstice NS, et al. Association of neonatal glycemia with neurodevelopmental outcomes at 4.5 years. JAMA Pediatr. 2017; 171( 10): 972– 983; doi: 10.1001/jamapediatrics.2017.1579OpenUrlCrossRef

Investigators from multiple institutions conducted a prospective cohort study to assess neurodevelopmental outcomes of children exposed to neonatal hypoglycemia. Children born at ≥32 weeks’ gestation with ≥1 risk factor for neonatal hypoglycemia (diabetic mother, <37 weeks’ gestation, small for gestational age [<10th percentile or <2,500 g], large for gestational age [>90th percentile or >4,500 g], acute illness) were eligible. Enrolled infants had intermittent whole-blood glucose levels measured per a clinical protocol or underwent continuous interstitial glucose monitoring for ≤7 days. Blood glucose concentrations of <47 mg/dL (<2.61 mmol/L) were treated with additional feeding or buccal or intravenous dextrose.

The primary exposure was hypoglycemia, defined as ≥1 episode of blood glucose concentration of <47 mg/dL (<2.61 mmol/L) or a continuous glucose concentration of <47 mg/dL (<2.61 mmol/L) for ≥10 minutes within the first week of …

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AAP Grand Rounds
Vol. 38, Issue 5
1 Nov 2017
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Neurodevelopment After Neonatal Hypoglycemia
AAP Grand Rounds Nov 2017, 38 (5) 53; DOI: 10.1542/gr.38-5-53

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AAP Grand Rounds Nov 2017, 38 (5) 53; DOI: 10.1542/gr.38-5-53
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