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Investigators from multiple institutions conducted a multicenter, prospective, observational study to compare the effectiveness of β-lactam monotherapy (BL) versus β-lactam plus macrolide combination therapy (BL+) in the treatment of pneumonia in hospitalized children. Children <18 years of age were eligible if they were hospitalized at 1 of 3 US children’s hospitals with signs or symptoms of acute infection, acute respiratory illness, and radiographic evidence of pneumonia. Study staff conducted chart reviews of all enrolled participants for demographic and clinical information, including …
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