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Investigators from multiple Japanese institutions conducted a retrospective observational study to assess the long-term clinical course among children with frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome (SDNS) treated after treatment with rituximab. Patients with childhood-onset FRNS or SDNS, who had received 375 mg/m2 rituximab once weekly for 4 weeks as part of a clinical trial conducted from 2008–2010, were eligible to participate. FRNS was defined as ≥4 relapses of nephrotic syndrome within any 12-month period. SDNS was defined as 2 consecutive relapses during tapering or within 2 …
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