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Investigators from multiple institutions in the United Kingdom and Canada conducted a prospective observational study to characterize bruising in young children with bleeding disorders. Study participants were patients <6 years old recruited from 6 hemophilia centers. These children were characterized as having either a severe bleeding disorder (levels of factors VIII/IX or XI <1 IU/dL or type 3 von Willebrand disease [vWD]) or a mild/moderate disorder (levels >1 IU/dL or type 1 or 2 vWD). A comparison group of control children without bleeding disorders was also enrolled. The developmental status of participants was categorized as premobile, early mobile (crawling and/or cruising), or walking. On a weekly basis for 12 weeks, parents …
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