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American Academy of Pediatrics
Hematology-Oncology

Childhood Cancer Survivors at Risk for Brain Tumors

AAP Grand Rounds March 2018, 39 (3) 33; DOI: https://doi.org/10.1542/gr.39-3-33
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Source: Wang X, Sun CL, Hageman L, et al. Clinical and genetic risk prediction of subsequent CNS tumors in survivors of childhood cancer: a report from the COG ALTE03N1 study. J Clin Oncol. 2017; 35( 32): 3688– 3696; doi: 10.1200/JCO.2017.74.7444OpenUrlCrossRef

Investigators from multiple institutions conducted a case-control study to identify single nucleotide polymorphisms (SNPs) in several candidate genes that are associated with subsequent central nervous system (CNS) tumors in survivors of childhood cancer and constructed predictive models to identify individuals at high risk for subsequent CNS tumors using clinical information alone, or with genetic data included. Cases were patients treated at a Children’s Cancer Oncology Group (COG) institution with a primary cancer diagnosis at <21 years of age who subsequently developed a histologically distinct CNS tumor. Up to 4 controls were matched to each case. Samples of blood or saliva from study participants were …

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AAP Grand Rounds
Vol. 39, Issue 3
1 Mar 2018
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Childhood Cancer Survivors at Risk for Brain Tumors
AAP Grand Rounds Mar 2018, 39 (3) 33; DOI: 10.1542/gr.39-3-33

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Childhood Cancer Survivors at Risk for Brain Tumors
AAP Grand Rounds Mar 2018, 39 (3) 33; DOI: 10.1542/gr.39-3-33
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