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Investigators from multiple institutions conducted a case-control study to identify single nucleotide polymorphisms (SNPs) in several candidate genes that are associated with subsequent central nervous system (CNS) tumors in survivors of childhood cancer and constructed predictive models to identify individuals at high risk for subsequent CNS tumors using clinical information alone, or with genetic data included. Cases were patients treated at a Children’s Cancer Oncology Group (COG) institution with a primary cancer diagnosis at <21 years of age who subsequently developed a histologically distinct CNS tumor. Up to 4 controls were matched to each case. Samples of blood or saliva from study participants were …
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