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Investigators from multiple institutions conducted a randomized, placebo-controlled trial to study the long-term efficacy and safety of inhaled budesonide for the prevention of bronchopulmonary dysplasia (BPD) in extremely premature infants. Infants were included if they were born between a gestational age of 23 weeks 0 days and 27 weeks 6 days and required any form of positive-pressure respiratory support. Participants were randomly assigned to receive either placebo or 2 puffs (200 μg per puff) of budesonide every 12 hours in the first 14 days of life followed by 1 puff administered every 12 hours from …
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