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American Academy of Pediatrics
Hospital Medicine

Frequency of Herpes Simplex Virus Infection in Infants

AAP Grand Rounds May 2018, 39 (5) 56; DOI: https://doi.org/10.1542/gr.39-5-56
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Source: Cruz AT, Freedman SB, Kulik DM, et al. Herpes simplex virus infection in infants undergoing meningitis evaluation. Pediatrics. 2018; 141( 2): e20171688; doi: 10.1542/peds.2017-1688OpenUrlAbstract/FREE Full Text

Investigators at multiple institutions conducted a retrospective cross-sectional study of ED encounters to determine the frequency of herpes simplex virus (HSV) infection in infants. Infants ≤60 days old assessed for central nervous system (CNS) infection in 1 of 23 participating EDs from 2005–2013 were included. Presence of a cerebrospinal fluid (CSF) bacterial culture in an infant’s medical record within 24 hours of ED arrival was used to identify ED encounters that involved assessment of an infant for CNS infection. Infant demographics, clinical course, viral culture/polymerase chain reaction (PCR) results, and use of antiviral therapy were extracted from the medical records of eligible ED encounters.

The primary outcome was HSV infection, defined as HSV detected by PCR and/or viral culture …

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AAP Grand Rounds
Vol. 39, Issue 5
1 May 2018
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Frequency of Herpes Simplex Virus Infection in Infants
AAP Grand Rounds May 2018, 39 (5) 56; DOI: 10.1542/gr.39-5-56

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Frequency of Herpes Simplex Virus Infection in Infants
AAP Grand Rounds May 2018, 39 (5) 56; DOI: 10.1542/gr.39-5-56
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