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Investigators from the California Department of Public Health (CDPH), Richmond, CA, and the University of California, Berkeley, CA, conducted a retrospective study to assess the efficacy of Human Botulism Immune Globulin (BIG-IV) in treating infant botulism. CDPH developed BIG-IV, which was licensed in 2003, and CDPH is the sole source of BIG-IV in the United States. For the study, the investigators reviewed the medical records of all patients with laboratory-confirmed infant botulism in the United States treated with BIG-IV from 2003 to 2015. The primary outcomes were length of stay (LOS) and hospital charges. Outcomes in children treated with BIG-IV were compared to those of patients receiving placebo in the BIG-IV Pivotal Trial, conducted from …
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