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American Academy of Pediatrics
Infectious Diseases

Human Botulism Immune Globulin for Treatment of Infant Botulism

AAP Grand Rounds July 2018, 40 (1) 3; DOI: https://doi.org/10.1542/gr.40-1-3
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Source: Payne JR, Khouri JM, Jewell NP, et al. Efficacy of human botulism immune globulin for the treatment of infant botulism: the first 12 years post licensure. J Pediatr. 2018; 193: 172– 177; doi: 10.1016/j.jpeds.2017.10.035OpenUrlCrossRef

Investigators from the California Department of Public Health (CDPH), Richmond, CA, and the University of California, Berkeley, CA, conducted a retrospective study to assess the efficacy of Human Botulism Immune Globulin (BIG-IV) in treating infant botulism. CDPH developed BIG-IV, which was licensed in 2003, and CDPH is the sole source of BIG-IV in the United States. For the study, the investigators reviewed the medical records of all patients with laboratory-confirmed infant botulism in the United States treated with BIG-IV from 2003 to 2015. The primary outcomes were length of stay (LOS) and hospital charges. Outcomes in children treated with BIG-IV were compared to those of patients receiving placebo in the BIG-IV Pivotal Trial, conducted from …

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AAP Grand Rounds
Vol. 40, Issue 1
1 Jul 2018
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Human Botulism Immune Globulin for Treatment of Infant Botulism
AAP Grand Rounds Jul 2018, 40 (1) 3; DOI: 10.1542/gr.40-1-3

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Human Botulism Immune Globulin for Treatment of Infant Botulism
AAP Grand Rounds Jul 2018, 40 (1) 3; DOI: 10.1542/gr.40-1-3
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