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American Academy of Pediatrics
Hematology-Oncology

Platelet Transfusion Trial in Neonatal Thrombocytopenia

AAP Grand Rounds February 2019, 41 (2) 19; DOI: https://doi.org/10.1542/gr.41-2-19
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Source: Curley A, Stanworth SJ, Willoughby K, et al. Randomized trial of platelet-transfusion thresholds in neonates [published online ahead of print November 2, 2018]. N Engl J Med. doi: 10.1056/NEJMoa1807320OpenUrlCrossRef

Investigators from multiple institutions conducted a randomized trial to assess clinical effects of a low or high threshold for platelet transfusions in premature infants with severe thrombocytopenia. Study participants were neonates born at <34 weeks’ gestation with platelet counts <50,000 per mm3 who were cared for at centers in Ireland, the United Kingdom, or the Netherlands. At enrollment, participating infants were randomized to receive platelet transfusions when their platelet counts were <50,000 per mm3 (high-threshold group) or <25,000 per mm3 (low-threshold group), as needed for surgery or invasive procedures, or because of a severe bleeding episode. Study participants were followed up for 28 days after enrollment. The primary study outcome was a composite of death or a major bleeding episode during the 28-day study period. …

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AAP Grand Rounds
Vol. 41, Issue 2
1 Feb 2019
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Platelet Transfusion Trial in Neonatal Thrombocytopenia
AAP Grand Rounds Feb 2019, 41 (2) 19; DOI: 10.1542/gr.41-2-19

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Platelet Transfusion Trial in Neonatal Thrombocytopenia
AAP Grand Rounds Feb 2019, 41 (2) 19; DOI: 10.1542/gr.41-2-19
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