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Investigators from multiple institutions conducted a secondary analysis of data collected during a large prospective study in febrile infants ≤60 days old to assess the risk of serious bacterial infection (SBI) in patients with a documented viral infection. The original study was conducted by the Pediatric Emergency Care Applied Research Network and included children ≤60 days old, with a temperature >38.0°C, presenting to 1 of 26 EDs. Demographic information, physical examination findings, and laboratory results were collected for enrolled patients. For the current analysis, only study participants who were tested for at least one virus were included. The primary study outcome was the presence of an SBI, including UTI, bacteremia, or bacterial …
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