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Investigators from multiple institutions conducted a systematic review to assess clinical outcomes associated with sickle cell trait (SCT). Databases such as PubMed and the Cochrane Library were searched for English-language research articles published between 1970 and 2018 that reported on associations between SCT and 24 clinical outcomes grouped into 6 categories (exertion-related injury, renal, vascular, pediatric, surgery or trauma related, and overall mortality). Articles were excluded if they did not use a valid method of genotyping all study participants, did not have a non-SCT comparison group, or did not list outcomes for non-SCT carriers.
Two independent reviewers assessed …
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