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Investigators from multiple institutions conducted a retrospective cohort study to describe rates of patent ductus arteriosus (PDA) closure in preterm infants. Infants were eligible if they were (a) born in the study hospital between 2004 and 2013, (b) were between 24 0/7 and 29 6/7 gestational ages or had a birth weight of <1,250 g, (c) were admitted within 48 hours of birth, (d) were discharged alive, and (e) had a PDA at routine echocardiography performed between 48 and 72 hours of life. Infants were categorized as having hemodynamically significant (HS) or hemodynamically insignificant (HI) PDAs, the former defined as a duct diameter >1.5 mm, a left atrium-to-aorta ratio >1.4, and/or an end-diastolic reversal flow …
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