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Investigators from multiple institutions conducted a prospective observational study to develop a prediction rule for identifying febrile infants at low risk for serious bacterial illness (SBI). Infants <60 days old presenting to a study ED with a rectal temperature of ≥38°C were eligible. For all patients, treating ED physicians recorded their clinical suspicion of SBI risk and provided an assessment using the Yale Observation Scale (YOS). A complete blood count with differential, serum procalcitonin, urinalysis (UA), and blood and urine cultures were also obtained from all patients, while cerebrospinal fluid was obtained at physician discretion.
The primary outcome was SBI, defined as …
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