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Investigators from multiple institutions in Australia conducted a prospective cohort study comparing clinical features, management, and outcomes in children with a first febrile seizure (FS) occurring soon after vaccination (vaccine-proximate febrile seizure [VP-FS]) and those with a nonvaccine-proximate febrile seizure (NVP-FS). Study participants were children <6 years old presenting to 1 of 5 hospitals in Australia between May 2013 and June 2014 with a first seizure associated with a temperature >38°C; patients with preexisting neurologic conditions and those with a central nervous system infection were excluded. Children with an FS occurring within 2 days after receiving inactivated vaccine, 5–14 days after receiving a live-attenuated vaccine, or 0–14 days after receiving a combination live and inactivated vaccine were classified …
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