This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Investigators from multiple institutions conducted a simulation study to assess the duration of immunity and effectiveness of diphtheria-tetanus-acellular pertussis (DTaP) vaccines in US children. Investigators used a validated population-based pertussis transmission model based on incidence data from Massachusetts for this simulation.1 This model was able to account for postvaccine infections in previously vaccinated individuals that were caused by primary vaccine failure or failure in vaccine duration.
Simulations using this model were conducted in 5 cohorts of 5- to 9-year-old children born between 2001 and 2005. Investigators compared the simulated dynamics of pertussis in these cohorts with epidemiological studies of pertussis in the United States. In particular, investigators varied the degree of DTaP waning in the simulated cohorts to determine which degree of DTaP …
Individual Login
Institutional Login
You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.
