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American Academy of Pediatrics
Gastroenterology

Short Course of Treatment for Hepatitis C in Adolescents

AAP Grand Rounds October 2019, 42 (4) 41; DOI: https://doi.org/10.1542/gr.42-4-41
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Source: El-Khayat H, Kamal EM, Yakoot M, et al. Effectiveness of 8-week sofosbuvir/ledipasvir in the adolescent chronic hepatitis C-infected patients. Eur J Gastroenterol Hepatol. 2019; 31( 8): 1004– 1009; doi: 10.1097/MEG.0000000000001360OpenUrlCrossRef

Investigators from multiple institutions in Egypt conducted a randomized trial assessing the efficacy and safety of sofosbuvir/ledipasvir (SOF/LVD) for 8 weeks, compared to 12 weeks, for treatment of genotype 4 hepatitis C virus (HCV) infection in adolescents 12–17 years old. Study patients were randomized to a single daily dose of a combination of SOF 400 mg and LVD 90 mg for either 8 or 12 weeks. At baseline, participants underwent a FibroScan to assess liver fibrosis using a standardized classification system. Laboratory screening was conducted at baseline and throughout the 12-week study period to measure HCV RNA and assess for possible adverse events; study participants reported adverse events. The primary study outcome was the sustained virologic response (SVR) rate, defined …

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AAP Grand Rounds
Vol. 42, Issue 4
1 Oct 2019
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Short Course of Treatment for Hepatitis C in Adolescents
AAP Grand Rounds Oct 2019, 42 (4) 41; DOI: 10.1542/gr.42-4-41

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Short Course of Treatment for Hepatitis C in Adolescents
AAP Grand Rounds Oct 2019, 42 (4) 41; DOI: 10.1542/gr.42-4-41
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