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Investigators conducted a multicenter, randomized, double-blind, noninferiority trial to compare the effect of ibuprofen to that of acetaminophen on post-tonsillectomy bleeding (PTB) in children. Children aged 2–18 years who presented to 1 of 4 study institutions for extracapsular tonsillectomy for sleep-disordered breathing or obstructive sleep apnea, adenotonsillar hypertrophy, or infectious tonsillitis were eligible. Children with known personal or family history of a bleeding disorder were excluded.
Participants were randomized to receive either 15 mg/kg of acetaminophen every 6 hours or 10 mg/kg of ibuprofen every 6 hours for the first 9 postoperative days for analgesia. Participants, parents, and clinicians were all blinded to treatment, with acetaminophen and ibuprofen …
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