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Investigators from Seattle Children’s Hospital and the University of California, San Francisco, conducted a retrospective analysis to develop a 2-variable clinical prediction rule to quantify the risk of rebound hyperbilirubinemia in newborns who undergo phototherapy. The prediction rule included a newborn’s gestational age and the difference between the AAP-recommended threshold total serum bilirubin (TSB) level at the time that phototherapy was initiated and the TSB level at the time that phototherapy was discontinued (TSB difference).1 To develop the prediction rule, the authors abstracted medical record data in newborns born at ≥35 weeks’ gestation at Kaiser Permanente Northern California hospitals between 2012 and 2014 who underwent inpatient phototherapy.
The study sample was randomly divided into a derivation sample to develop the prediction rule and a validation sample to assess its clinical …
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