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Investigators at multiple Australian institutions conducted a randomized controlled trial to assess the efficacy of 3 oral steroid regimens in the treatment of croup. Patients were eligible if they presented to 1 of 2 study EDs between 2009–2012, were clinically diagnosed with croup, and were >6 months old. Patients were excluded if they had a known steroid allergy or were already on oral steroids. Demographics of enrolled participants were collected at baseline.
Participants were randomized to receive either 0.6 mg/kg dexamethasone (DEX), low-dose (0.15 mg/kg) dexamethasone (LD-DEX), or 1 mg/kg prednisolone (PRED). Staff and patients were blinded to treatment allocation. Each participant was assessed at baseline and 1-hour post-treatment using a validated measure of croup severity: the Westley croup score (WCS). The …
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