Predicting IVIg Nonresponse in Children With Kawasaki Disease

Investigators from multiple institutions conducted a retrospective study to develop a model for predicting which children with Kawasaki disease (KD) will be IV immunoglobulin (IVIg) nonresponders in hopes of identifying low-risk patients who could be discharged from the hospital earlier after receiving an initial dose of IVIg. Study participants were children 0–18 years old with a primary diagnosis of KD and hospitalized at a single, large, urban US children’s hospital. The medical records of study participants were reviewed, and clinical and laboratory data abstracted. The primary study outcome was IVIg nonresponse defined by one or more of the following criteria: (a) documented fever (temperature ≥38.0°C) 36 hours to 7 days after completion of IVIg dose, (b) receipt …