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Investigators from Amsterdam University Medical Centers, Amsterdam, and Imagelabonline and Cardiovascular, Erichem, both in the Netherlands, conducted a study assessing long-term outcomes in children treated with statins for familial hypercholesterolemia with elevated low-density lipoprotein (LDL) cholesterol. Study participants were children with familial hypercholesterolemia (98% genetically confirmed) and their unaffected siblings who had originally participated in a randomized controlled trial on the efficacy and safety of pravastatin, with enrollment between 1997 and 1999. These individuals were recontacted and asked to complete a questionnaire detailing subsequent medical history, lifestyle habits, medication use, and family history. In addition, study participants had carotid intima-media thickness assessed with ultrasonography at baseline and follow-up. Primary study outcomes included change in carotid intima-media thickness …
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