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Investigators from Wilhelmina Children’s Hospital, Utrecht, Netherlands, and The Hospital for Sick Children, Toronto, Canada, conducted a prospective observational cohort study of infants with critical congenital heart disease (CHD) to assess prevalence of and risk factors for acquired brain injury after cardiac surgery. Children with critical CHD who underwent open heart surgery with cardiopulmonary bypass (CPB) at ≤60 days after birth at the 2 study hospitals from 2016 to 2017 were included. Demographic characteristics were collected at baseline.
The primary predictor variables included pre- and postoperative clinical characteristics, including CHD lesion, Apgar score, delivery mode, gestational age, balloon atrioseptostomy, postoperative low cardiac output syndrome (LCOS; defined as lactate >4 …
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