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American Academy of Pediatrics
Nephrology

Longer Initial Prednisolone Treatment of Nephrotic Syndrome Is Not Better

AAP Grand Rounds March 2020, 43 (3) 32; DOI: https://doi.org/10.1542/gr.43-3-32
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Source: Webb NJA, Woolley RL, Lambe T, et al. Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation. BMJ. 2019; 365: l1800; doi: 10.1136/bmj.l1800OpenUrlAbstract/FREE Full Text

Investigators from multiple institutions in the United Kingdom conducted a randomized controlled trial to compare the effectiveness of a prolonged tapering regimen of prednisolone to the standard regimen in childhood nephrotic syndrome. Study participants were children 1–14 years old with their first episode of steroid-sensitive nephrotic syndrome. Eligibility requirements included a ratio of first morning urine protein (or albumin) to creatinine >200 mg/mmol, serum or plasma albumin level <25 g/L, and no previous treatment with corticosteroids. All study patients were treated with prednisolone 60 mg/m2 daily for 4 weeks at which point they were randomized …

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AAP Grand Rounds
Vol. 43, Issue 3
1 Mar 2020
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Longer Initial Prednisolone Treatment of Nephrotic Syndrome Is Not Better
AAP Grand Rounds Mar 2020, 43 (3) 32; DOI: 10.1542/gr.43-3-32

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Longer Initial Prednisolone Treatment of Nephrotic Syndrome Is Not Better
AAP Grand Rounds Mar 2020, 43 (3) 32; DOI: 10.1542/gr.43-3-32
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