High-Versus Low-Dose Aspirin in the Treatment of Kawasaki Disease

Investigators from Indiana University, Indianapolis, IN, conducted a retrospective study to compare rates of recrudescent fever and coronary artery (CA) abnormalities in children treated with IV immunoglobulin (IVIG) and either low- or high-dose aspirin (ASA) for treatment of Kawasaki disease (KD). Study participants were children with KD treated within 10 days of symptom onset with 2 g/kg of IVIG and ASA at Riley’s Hospital for Children, Indianapolis, IN, between 2007 and 2018. Eligible children were identified using ICD-9 and ICD-10 codes; the medical records of eligible children were reviewed, and information was abstracted on demographics, symptoms before admission, clinical course during hospitalization and follow-up, echocardiography results, and dose of ASA. Initial ASA doses were categorized as low (<10 mg/kg/d) or high …