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Investigators from the University of Copenhagen and Naestved Hospital, Denmark, conducted a double-blind randomized controlled trial to assess the effect of high- versus standard-dose vitamin D supplementation during pregnancy on anthropometrics and bone mineralization in children through age 6 years. Pregnant women at 24 weeks’ gestation and living in Zealand, Denmark, were eligible to participate. Participants were randomized 1:1 to receive a daily dose of 2,400 IU of cholecalciferol (vitD3) or matching placebo capsules from 24 weeks’ gestation until 1 week postpartum. All participants were encouraged to continue their daily intake of 400 IU of vitD3, so the study compared participants taking 2,800 IU (high dose) versus 400 IU of vitD3 (standard dose). Participant 25(OH)D levels …
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