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Investigators from multiple institutions conducted a longitudinal, partially retrospective, observational study to assess outcomes among boys with severe hemophilia A (HA) who started factor VIII (FVIII) prophylaxis before age 2.5 years compared to those who started prophylaxis after age 6 years. This was a continuation study of the Joint Outcome Study (JOS), a randomized control trial of 65 boys with severe HA who were < 2.5 years old to receive either FVIII prophylaxis every other day or episodic FVIII only at the time of joint hemorrhage. It was found that FVIII prophylaxis resulted in significantly less joint osteochondral damage by 6 years of age.1 As a result, all JOS …
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