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Investigators from multiple institutions conducted a prospective study to identify risk factors for early death among youths and young adults with sickle cell disease (SCD). Participants were SCD patients, 3–20 years old, seen at 1 of 4 medical centers and enrolled between 2006 and 2010. At baseline, demographic and medical history data were collected, including information regarding previous stroke, history of transfusions, severe pain episodes, and a diagnosis of asthma. Blood samples were collected for determination of multiple tests, including serum ferritin levels and neutrophil count. Pulmonary function testing was done and an echocardiogram performed. The main hypothesis was that increased tricuspid regurgitation velocity (TRV) seen on echocardiogram, as a marker for increased systolic pulmonary pressure, would …
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